Gene name:
Sptan1 (Spna2;Spta2) ;
Protein name:
Spectrin alpha chain, brain ;
Alternative:
Fodrin alpha chain ;Alpha-II spectrin ;Spectrin, non-erythroid alpha chain ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts with ACP1. Interacts with CALM and EMD (By similarity). Interacts (via C-terminal spectrin repeats) with TRPC4 (By similarity). Identified in a complex with ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1.
Function:
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Subcellular Location:
Cytoplasm
cytoskeleton
Cytoplasm
cell cortex
Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells.
Protein Attributes:
50:
MDPSGVKVLE | TAEDIQERRQ | QVLDRYHRFK | ELSTLRRQKL | EDSYRFQFFQ |
100:
RDAEELEKWI | QEKLQVASDE | NYKDPTNLQG | KLQKHQAFEA | EVQANSGAIV |
150:
KLDETGNLMI | SEGHFASETI | RTRLMELHRQ | WELLLEKMRE | KGIKLLQAQK |
200:
LVQYLRECED | VMDWINDKEA | IVTSEELGQD | LEHVEVLQKK | FEEFQTDLAA |
250:
HEERVNEVSQ | FAAKLIQEQH | PEEELIKTKQ | DEVNAAWQRL | KGLALQRQGK |
300:
LFGAAEVQRF | NRDVDETIGW | IKEKEQLMAS | DDFGRDLASV | QALLRKHEGL |
350:
ERDLAALEDK | VKALCAEADR | LQQSHPLSAS | QIQVKREELI | TNWEQIRTLA |
400:
AERHARLDDS | YRLQRFLADF | RDLTSWVTEM | KALINADELA | NDVAGAEALL |
450:
DRHQEHKGEI | DAHEDSFKSA | DESGQALLAA | SHYASDEVRE | KLSILSEERT |
500:
ALLELWELRR | QQYEQCMDLQ | LFYRDTEQVD | NWMSKQEAFL | LNEDLGDSLD |
550:
SVEALLKKHE | DFEKSLSAQE | EKITALDEFA | TKLIQNNHYA | MEDVATRRDA |
600:
LLSRRNALHE | RAMHRRAQLA | DSFHLQQFFR | DSDELKSWVN | EKMKTATDEA |
650:
YKDPSNLQGK | VQKHQAFEAE | LSANQSRIDA | LEKAGQKLID | VNHYAKEEVA |
700:
ARMNEVISLW | KKLLEATELK | GIKLREANQQ | QQFNRNVEDI | ELWLYEVEGH |
750:
LASDDYGKDL | TNVQNLQKKH | ALLEADVAAH | QDRIDGITIQ | ARQFQDAGHF |
800:
DAENIKKKQE | ALVARYEALK | EPMVARKQKL | ADSLRLQQLF | RDVEDEETWI |
850:
REKEPIAAST | NRGKDLIGVQ | NLLKKHQALQ | AEIAGHEPRI | KAVTQKGNAM |
900:
VEEGHFAAED | VKAKLSELNQ | KWEALKAKAS | QRRQDLEDSL | QAQQYFADAN |
950:
EAESWMREKE | PIVGSTDYGK | DEDSAEALLK | KHEALMSDLS | AYGSSIQALR |
1000:
EQAQSCRQQV | APMDDETGKE | LVLALYDYQE | KSPREVTMKK | GDILTLLNST |
1050:
NKDWWKVEVN | DRQGFVPAAY | VKKLDPAQSA | SRENLLEEQG | SIALRQGQID |
1100:
NQTRITKEAG | SVSLRMKQVE | ELYQSLLELG | EKRKGMLEKS | CKKFMLFREA |
1150:
NELQQWITEK | EAALTNEEVG | ADLEQVEVLQ | KKFDDFQKDL | KANESRLKDI |
1200:
NKVAEDLESE | GLMAEEVQAV | QQQEVYGAMP | RDEADSKTAS | PWKSARLMVH |
1250:
TVATFNSIKE | LNERWRSLQQ | LAEERSQLLG | SAHEVQRFHR | DADETKEWIE |
1300:
EKNQALNTDN | YGHDLASVQA | LQRKHEGFER | DLAALGDKVN | SLGETAQRLI |
1350:
QSHPESAEDL | KEKCTELNQA | WTSLGKRADQ | RKAKLGDSHD | LQRFLSDFRD |
1400:
LMSWINGIRG | LVSSDELAKD | VTGAEALLER | HQEHRTEIDA | RAGTFQAFEQ |
1450:
FGQQLLAHGH | YASPEIKEKL | DILDQERTDL | EKAWVQRRMM | LDHCLELQLF |
1500:
HRDCEQAENW | MAAREAFLNT | EDKGDSLDSV | EALIKKHEDF | DKAINVQEEK |
1550:
IAALQAFADQ | LIAVDHYAKG | DIANRRNEVL | DRWRRLKAQM | IEKRSKLGES |
1600:
QTLQQFSRDV | DEIEAWISEK | LQTASDESYK | DPTNIQSKHQ | KHQAFEAELH |
1650:
ANADRIRGVI | DMGNSLIERG | ACAGSEDAVK | ARLAALADQW | QFLVQKSAEK |
1700:
SQKLKEANKQ | QNFNTGIKDF | DFWLSEVEAL | LASEDYGKDL | ASVNNLLKKH |
1750:
QLLEADISAH | EDRLKDLNSQ | ADSLMTSSAF | DTSQVKEKRD | TINGRFQKIK |
1800:
SMATSRRAKL | SESHRLHQFF | RDMDDEESWI | KEKKLLVSSE | DYGRDLTGVQ |
1850:
NLRKKHKRLE | AELAAHEPAI | QGVLDTGKKL | SDDNTIGQEE | IQQRLAQFVE |
1900:
HWKELKQLAA | ARGQRLEESL | EYQQFVANVE | EEEAWINEKM | TLVASEDYGD |
1950:
TLAAIQGLLK | KHEAFETDFT | VHKDRVNDVC | TNGQDLIKKN | NHHEENISSK |
2000:
MKGLNGKVSD | LEKAAAQRKA | KLDENSAFLQ | FNWKADVVES | WIGEKENSLK |
2050:
TDDYGRDLSS | VQTLLTKQET | FDAGLQAFQQ | EGIANITALK | DQLLAAKHIQ |
2100:
SKAIEARHAS | LMKRWTQLLA | NSATRKKKLL | EAQSHFRKVE | DLFLTFAKKA |
2150:
SAFNSWFENA | EEDLTDPVRC | NSLEEIKALR | EAHDAFRSSL | SSAQADFNQL |
2200:
AELDRQIKSF | RVASNPYTWF | TMEALEETWR | NLQKIIKERE | LELQKEQRRQ |
2250:
EENDKLRQEF | AQHANAFHQW | IQETRTYLLD | GSCMVEESGT | LESQLEATKR |
2300:
KHQEIRAMRS | QLKKIEDLGA | AMEEALILDN | KYTEHSTVGL | AQQWDQLDQL |
2350:
GMRMQHNLEQ | QIQARNTTGV | TEEALKEFSM | MFKHFDKDKS | GRLNHQEFKS |
2400:
CLRSLGYDLP | MVEEGEPDPE | FEAILDTVDP | NRDGHVSLQE | YMAFMISRET |
2450:
ENVKSSEEIE | SAFRALSSEG | KPYVTKEELY | QNLTREQADY | CVSHMKPYVD |
2472:
GKGRELPTAF | DYVEFTRSLF | VN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Human
Rat
Mouse
Chicken
Chicken
Rat
ELISA Kit for Mouse Spectrin alpha chain, brain
ELISA Kit for Mouse Spectrin alpha chain, brain
ELISA Kit for Mouse Spectrin alpha chain, brain
ELISA Kit for Mouse Spectrin alpha chain, brain
ELISA Kit for Mouse Spectrin alpha chain, brain
ELISA Kit for Mouse Spectrin alpha chain, brain
ELISA Kit for Mouse Spectrin alpha chain, brain
ELISA Kit for Mouse Spectrin alpha chain, brain
CLIA Kit for Mouse Spectrin alpha chain, brain
CLIA Kit for Mouse Spectrin alpha chain, brain
CLIA Kit for Mouse Spectrin alpha chain, brain
CLIA Kit for Mouse Spectrin alpha chain, brain
CLIA Kit for Mouse Spectrin alpha chain, brain
CLIA Kit for Mouse Spectrin alpha chain, brain
CLIA Kit for Mouse Spectrin alpha chain, brain
CLIA Kit for Mouse Spectrin alpha chain, brain
Polyclonal Antibody for Mouse Spectrin alpha chain, brain
Polyclonal Antibody for Mouse Spectrin alpha chain, brain
Polyclonal Antibody for Mouse Spectrin alpha chain, brain
Polyclonal Antibody for Mouse Spectrin alpha chain, brain
Polyclonal Antibody for Mouse Spectrin alpha chain, brain
Polyclonal Antibody for Mouse Spectrin alpha chain, brain
Polyclonal Antibody for Mouse Spectrin alpha chain, brain
Polyclonal Antibody for Mouse Spectrin alpha chain, brain
Monoclonal Antibody for Mouse Spectrin alpha chain, brain
Monoclonal Antibody for Mouse Spectrin alpha chain, brain
Monoclonal Antibody for Mouse Spectrin alpha chain, brain
Monoclonal Antibody for Mouse Spectrin alpha chain, brain
Monoclonal Antibody for Mouse Spectrin alpha chain, brain
Monoclonal Antibody for Mouse Spectrin alpha chain, brain
Monoclonal Antibody for Mouse Spectrin alpha chain, brain
Monoclonal Antibody for Mouse Spectrin alpha chain, brain
Protein for Mouse Spectrin alpha chain, brain
Protein for Mouse Spectrin alpha chain, brain
Protein for Mouse Spectrin alpha chain, brain
Protein for Mouse Spectrin alpha chain, brain
Protein for Mouse Spectrin alpha chain, brain
Protein for Mouse Spectrin alpha chain, brain
Protein for Mouse Spectrin alpha chain, brain
Protein for Mouse Spectrin alpha chain, brain
R&D Technical Data
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Precision
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Recovery
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Linearity
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